Associate Scientist II, Process Development - Downstream

We are currently seeking an Associate Scientist II, Process Development - Downstream to join the Forge Biologics team. This is an exciting opportunity to assist in the execution of laboratory experiments and protocols for downstream process development efforts. The candidate will assist in process development protocols/studies to optimize procedures for unique viral vector platform process and to assist in the transfer of client programs. The Associate Scientist will work to meet production goals, notify management of any potential delays in the schedule, and make recommendations to resolve the issues. What You'll Do:

• Assist with overall maintenance of the production and testing facilities. This includes but may not be limited to performing quality systems checks, buffer preparation, autoclaving of media, packing of biohazard material, monitoring or sanitizing equipment, preparing facility for production campaigns, and periodic cleaning of incubators, centrifuges, FPLCs, biological safety cabinets (BSCs), and other equipment.
• Culturing cells, performing transfections and/or infections with seed vectors, harvesting and lysing cells, and purifying vectors using density gradients, FPLC, or other techniques
• Provide receipt and distribution of incoming raw materials for research, preclinical, and clinical manufacturing.
• Unpack reagents, maintaining proper cold storage, restock supplies in storerooms or laboratories.
• Quarantine and prepare incoming raw materials intended for preclinical or clinical manufacturing for inspection and release.
• Maintain proper inventories of raw materials and consumables.
• Prepare formulations and raw materials as specified in protocols without the introduction of contaminants.
• Prepare sterile reagents as dictated by procedures or management by filtration or steam autoclaving.
• Report any discrepancies from protocols/study procedures or any materials preparation problems to management.
• Package and ship finished product to clients in accordance with procedures and regulations.
• Assist in the training and direction of Associate Scientists

What You'll Bring:

• Bachelor’s Degree in Biology, Molecular Biology, Virology, Biochemistry or related discipline
• Practical experience with FPLC or other chromatography systems.
• Must be self-motivating, organized, and proactive.
• Strong technical aptitude including demonstrated experience in applying scientific reasoning to solve complex problems.
• Ability to work hours necessary to support production and/or product transfer activities.
• Ability to work in loud noise environments and in Personal Protective Equipment (PPE) and cleanroom gowning attire as needed.

Preferred:

• Master’s Degree in Biology, Molecular Biology, Virology, Biochemistry, or related discipline.
• Experience with pilot and large-scale FPLC systems
• Experience with other aspects of downstream purification (e.g. – clarification/filtration, TFF, etc.)

Work Environment and Physical Demands This position works in both a laboratory environment and typical office environment where the physical work demands will vary depending on the specific tasks and duties required of the job. The employee will be stationary (standing/sitting) for extended periods of time. Employees regularly wear personal protective equipment based on the task being performed. Must be able to work in a confined space, such as a clean room or laboratory environment. Ability to identify small details within the field of vision, distinguish between different colors, and accurately identify objects within a specific area. This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee. Duties, responsibilities and activities may change or new ones may be assigned. Forge Biologics is an equal opportunity employer dedicated to building an inclusive and diverse workforce. Forge Biologics, provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. Life at Forge We are a team of diverse, driven and passionate people working together to trailblaze a new model for how we make medicines to treat patients with genetic diseases. Our team members use their creativity and talent to invent new solutions, meet new demands, and offer the most effective services in the industry. Forge’s core values lay the foundation for H.O.P.E. It provides us a common purpose that we all understand, work towards and live by. HARDWORKING - We work hard and smart, making a persistent and determined effort toward success. Working hard, with focus and desire is the key. OPEN - We strive to be approachable, actively listen and encourage others to contribute and speak up. We positively offer and receive constructive feedback. PURPOSE DRIVEN - We are passionate about working towards and delivering on our mission to manufacture gene therapies. ENGAGED - We are fully absorbed by and enthusiastic about our work and take positive action to further Forge’s vision, mission and goals. We’ve Got You Covered We take the health and happiness of our employees seriously and are consistently evaluating new ways to make our benefits truly UnFORGEttable. Health, Dental, and Vision insurance that starts on your first day at Forge, with 90% of premiums covered for team members as well as dependents Competitive paid time off plan Annual bonus for all full-time employees 401(K) company match Fully-stocked kitchen with free food/drinks 12 weeks of paid parental leave - additional discount programs include childcare support & dependent care Employee Assistance Program Wellness benefits (financial planning services, mental health counseling, employer paid disability) Onsite fitness facility Professional & Personal development resources Apply tot his job Apply To this Job